In this episode, which originally aired in radio format on March 3rd, 2022, I explore some of the ideas presented in William Styron's 1990 book, Darkness Visible: A Memoir of Madness. I also talk about Virginia Woolf's experiences with depression, as presented in Hermione Lee's biography of her, and about Francis Weller's perspective on the illness, as presented in his book The Wild Edge of Sorrow.